Chemistry:Haloperidol decanoate

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Short description: Typical antipsychotic medication
Haloperidol decanoate
Haloperidol decanoate.svg
Clinical data
Trade namesHalomonth, Haldol Decanoate, Haldol Decanoas, Haloperidol Decanoate, Haloperidol Decanoat, Neoperidole, Serenase Dekanoat
Other namesKD-136; R-13672
Routes of
administration		Intramuscular injection
Drug classTypical antipsychotic
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC31H41ClFNO3
Molar mass530.12 g·mol−1
3D model (JSmol)

Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia.[1][2][3][4] It is administered by injection into muscle at a dose of 100 to 200 mg once every 4 weeks or monthly.[5][6][7] The dorsogluteal site is recommended.[5] A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but obese individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously.[5] Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes.[5][6][8] Its elimination half-life after multiple doses is 21 days.[9][10] The medication is marketed in many countries throughout the world.[2][11]


See also

References

  1. ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 619–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA619. 
  2. ↑ 2.0 2.1 Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 509–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA509. 
  3. ↑ "Haloperidol decanoate". Pharmaceutical Substances: Syntheses, Patents and Applications of the most relevant APIs (5th ed.). Thieme. 2009. pp. 1376–. ISBN 978-3-13-179525-0. https://books.google.com/books?id=fO2IAwAAQBAJ&pg=PT1376. 
  4. ↑ Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012. pp. 139–. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA139. 
  5. ↑ 5.0 5.1 5.2 5.3 Psychologists' Psychotropic Drug Reference. Psychology Press. 1999. pp. 260–. ISBN 978-0-87630-964-3. https://books.google.com/books?id=n2e2aAYnZYkC&pg=PA260. 
  6. ↑ 6.0 6.1 Wyatt's Practical Psychiatric Practice: Forms and Protocols for Clinical Use. American Psychiatric Pub. 20 May 2008. pp. 142–. ISBN 978-1-58562-687-8. https://books.google.com/books?id=4ZUikjcnM2QC&pg=PA142. 
  7. ↑ Psychiatric Mental Health Nursing - E-Book. Elsevier Health Sciences. 13 June 2014. pp. 572–. ISBN 978-0-323-29327-3. https://books.google.com/books?id=xx8PDQAAQBAJ&pg=PA572. 
  8. ↑ Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. 2007. pp. 281–. ISBN 978-1-58528-136-7. https://books.google.com/books?id=v0rLyVSc8EYC&pg=PA281. 
  9. ↑ "Depot antipsychotic drugs. Place in therapy". Drugs 47 (5): 741–773. May 1994. doi:10.2165/00003495-199447050-00004. PMID 7520856. 
  10. ↑ "Release and absorption rate aspects of intramuscularly injected pharmaceuticals". International Journal of Pharmaceutics 47 (1–3): 1–12. 1988. doi:10.1016/0378-5173(88)90209-8. ISSN 0378-5173. 
  11. ↑ "Haloperidol Uses, Side Effects & Warnings". https://www.drugs.com/international/haloperidol.html. 



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