Chemistry:Fluorodeoxysorbitol
 Structural formula of [18F]-fluorodeoxysorbitol | |
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| Formula | C6H13FO5 |
| Molar mass | 184.163 g·mol−1 |
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[18F]-Fluorodeoxysorbitol (commonly called 18F-FDS) is a radiolabeled analog of the sugar alcohol sorbitol, in which a fluorine-18 (18F) radionuclide replaces the hydrogen at the 2-position. It is used as a radiotracer in positron emission tomography (PET) for imaging certain microbial infections and renal function.[1][2][3]
Synthesis
Chemically, 18F-FDS is 2-deoxy-2-[18F]-fluoro-D-sorbitol, a sorbitol analog modified by substitution of the 2-position hydrogen with radioactive fluorine-18. This modification preserves the structure sufficiently to be recognized and taken up by certain microbes that naturally metabolize sorbitol.[4][5]
One of the key advantages of fluorodeoxysorbitol is its relatively easy synthesis. It can be produced via a simple one-step reduction from [18F]-fluorodeoxyglucose, which is widely available in radiochemistry facilities. This provides easier production at facilities with PET-imaging capability.[6]
References
- ↑ Rua, Marta; Simón, Jon Ander; Collantes, María; Ecay, Margarita; Leiva, José; Carmona-Torre, Francisco; Ramos, Rocío; Pareja, Félix et al. (2023). "Infection-specific PET imaging with 18F-fluorodeoxysorbitol and 2-[18FF-ρ-aminobenzoic acid: An extended diagnostic tool for bacterial and fungal diseases"]. Frontiers in Microbiology 14. doi:10.3389/fmicb.2023.1094929. ISSN 1664-302X. PMID 36760503.
- ↑ Li, Junling; Zheng, Huaiyu; Olson, Jenna; Warawa, Jonathan M.; Ng, Chin K. (December 2024). "Differentiation Between Responders and Non-Responders to Antibiotic Treatment in Mice Using 18F-Fluorodeoxysorbitol/PET" (in en). Molecular Imaging and Biology 26 (6): 934–942. doi:10.1007/s11307-024-01957-3. ISSN 1536-1632. PMID 39407054. https://link.springer.com/10.1007/s11307-024-01957-3.
- ↑ Kim, Dong-Yeon; Pyo, Ayoung; Ji, Sehyeon; You, Sung-Hwan; Kim, Seong Eun; Lim, Daejin; Kim, Heejung; Lee, Kyung-Hwa et al. (2022-04-08). "In vivo imaging of invasive aspergillosis with 18F-fluorodeoxysorbitol positron emission tomography" (in en). Nature Communications 13 (1): 1926. doi:10.1038/s41467-022-29553-5. ISSN 2041-1723. PMID 35395822.
- ↑ Werner, Rudolf A.; Chen, Xinyu; Lapa, Constantin; Koshino, Kazuhiro; Rowe, Steven P.; Pomper, Martin G.; Javadi, Mehrbod S.; Higuchi, Takahiro (2019-08-01). "The next era of renal radionuclide imaging: novel PET radiotracers" (in en). European Journal of Nuclear Medicine and Molecular Imaging 46 (9): 1773–1786. doi:10.1007/s00259-019-04359-8. ISSN 1619-7089. PMID 31144061. PMC 6647203. https://doi.org/10.1007/s00259-019-04359-8.
- ↑ Rua, Marta; Simón, Jon Ander; Collantes, María; Ecay, Margarita; Leiva, José; Carmona-Torre, Francisco; Ramos, Rocío; Pareja, Félix et al. (2023-01-25). "Infection-specific PET imaging with 18F-fluorodeoxysorbitol and 2-[18FF-ρ-aminobenzoic acid: An extended diagnostic tool for bacterial and fungal diseases"]. Frontiers in Microbiology 14. doi:10.3389/fmicb.2023.1094929. ISSN 1664-302X. PMID 36760503.
- ↑ Werner, Rudolf A.; Ordonez, Alvaro A.; Sanchez-Bautista, Julian; Marcus, Charles; Lapa, Constantin; Rowe, Steven P.; Pomper, Martin G.; Leal, Jeffrey P. et al. (May 2019). "Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects" (in en). Clinical Nuclear Medicine 44 (5): 410–411. doi:10.1097/RLU.0000000000002494. ISSN 1536-0229. PMID 30762825.
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