Chemistry:Indium (111In) capromab pendetide
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| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Mouse |
| Target | Glutamate carboxypeptidase II |
| Clinical data | |
| Trade names | Prostascint |
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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).[1]
Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]
References
- ↑ 1.0 1.1 "Indium-111 capromab pendetide in the management of recurrent prostate cancer". Expert Review of Anticancer Therapy 8 (2): 175–81. February 2008. doi:10.1586/14737140.8.2.175. PMID 18279057.
- ↑ WHO Drug Information
- ↑ "A phase II study of [90Y] yttrium-capromab pendetide in the treatment of men with prostate cancer recurrence following radical prostatectomy". Cancer Biotherapy & Radiopharmaceuticals 14 (2): 99–111. April 1999. doi:10.1089/cbr.1999.14.99. PMID 10850293.
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