Chemistry:Fluorodopa
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| Trade names | Fluorodopa F18 |
| Other names | 6-fluoro-L-DOPA, FDOPA |
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| Routes of administration | Intravenous |
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| Formula | C9H10FNO4 |
| Molar mass | 214.18 g·mol−1 |
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Fluorodopa, also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).[1]
The most common side effects are injection site pain.[2]
Medical uses
Fluorodopa is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes (PS).[2]
History
In October 2019, Fluorodopa was approved in the United States for the visual detection of certain nerve cells in adult patients with suspected Parkinsonian Syndromes (PS).[3][4]
The U.S. Food and Drug Administration (FDA) approved Fluorodopa F 18 based on evidence from one clinical trial of 56 patients with suspected PS.[3] The trial was conducted at one clinical site in the United States.[3]
References
- ↑ "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry 13 (11): 1135–1140. June 2002. doi:10.1016/S0957-4166(02)00321-X.
- ↑ 2.0 2.1 "Fluorodopa F18 injection". 12 October 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=262503e7-de09-4b42-9963-ec00cbc7c35c.
- ↑ 3.0 3.1 3.2 "Drug Trials Snapshots: Fluorodopa F 18". 27 November 2019. https://www.fda.gov/drugs/drug-trials-snapshots-fluorodopa-f-18.
This article incorporates text from this source, which is in the public domain.
- ↑ "Drug Approval Package: Fluorodopa F18". 20 November 2019. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/200655Orig1s000TOC.cfm. This article incorporates text from this source, which is in the public domain.
External links
- "Fluorodopa F 18". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/rn/92812-82-3.
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