Chemistry:Isepamicin
From HandWiki
Isepamicin (isepamycin) is an aminoglycoside antibiotic.
It was patented in 1973 and approved for medical use in 1988.[1] It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.[2]
Synthesis
Isepamicin can be synthesized by derivatization of gentamicin B (1) with benzyl N-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate (2), followed by deprotection.[3][4][5][6]
References
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 508. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA508.
- ↑ "Critically important antimicrobials for human medicine.". World Health Organization. 2012. http://apps.who.int/iris/bitstream/10665/77376/1/9789241504485_eng.pdf.
- ↑ Serradell, MN; Blancafort, P.; Roberts, PJ; Castaer, J.; SCH-21420. Drugs Fut 1979, 4, 7, 525.
- ↑ John J. Wright, U.S. Patent 4,029,882 (1977 to Merck Sharp and Dohme Corp).
- ↑ Thieme
- ↑ ChemDrug
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