Chemistry:Dibekacin
From HandWiki
Dibekacin (3',4'-dideoxykanamycin B) is an aminoglycoside antibiotic. It is a semisynthetic derivative of kanamycin developed by Hamao Umezawa and collaborators for Meiji Seika,[1][2] and first patented in 1970.[3] It has been sold under a wide variety of trade names globally, including Orbicin,[4] Dibekacin Meiji,[5] Panimycin,[6] and Tokocin.[7] Clinical trials have found it to be effective against E. coli, Klebsiella, Enterobacter, Serratia, and Pseudomonas aeruginosa.[4][8]
It has been used in combination with sulbenicillin.[9]
References
- ↑ "3',4'-Dideoxy-Kanamycin B Active Against Kanamycin-Resistant Escherichia coli and Pseudomonas aeruginosa". The Journal of Antibiotics (Tokyo) 24 (7): 485–487. July 1971. doi:10.7164/antibiotics.24.485. PMID 4998037.
- ↑ "Découverte de la dibékacine et de ses aspects chimiques [Discovery of dibekacin and its chemical aspects]". La Nouvelle Presse Médicale 11 (46): 3379–3384. November 1982. PMID 7155844.
- ↑ Umezawa S, Umezawa H, Tsuchiya T, "The preparation of 3'-4'-dideoxykanamycin B active against resistant bacteria", US patent 3753973, published 1973-08-21, issued 1973-08-21, assigned to Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- ↑ 4.0 4.1 "[Dibekacin--a novel aminoglycoside antibioticl. Antimicrobial activity and parallel resistance in vitro]". Arzneimittel-Forschung 29 (2): 174–178. 1979. PMID 582126.
- ↑ "DIBEKACIN - Inxight Drugs". National Center for Advancing Translational Sciences. https://drugs.ncats.io/drug/45ZFO9E525.
- ↑ "Panimycin Injection 50mg". Japan Drug Information Institute Development Center. https://www.rad-ar.or.jp/siori/english/search/result?n=35684.
- ↑ PubChem. "Dibekacin (Compound)". National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/Dibekacin#section=MeSH-Entry-Terms.
- ↑ "In vitro comparison of kanamycin, kanendomycin, gentamicin, amikacin, sisomicin, and dibekacin against 200 strains of Pseudomonas aeruginosa". Antimicrobial Agents and Chemotherapy 14 (3): 514–515. September 1978. doi:10.1128/aac.14.3.514. PMID 101135.
- ↑ "Electron microscopy of Pseudomonas aeruginosa treated with sulbenicillin and dibekacin". The Tohoku Journal of Experimental Medicine 152 (2): 119–128. June 1987. doi:10.1620/tjem.152.119. PMID 3114912.
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