Chemistry:Troleandomycin
From HandWiki
Short description: Chemical compound
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AHFS/Drugs.com | Multum Consumer Information |
MedlinePlus | a604026 |
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Formula | C41H67NO15 |
Molar mass | 813.979 g·mol−1 |
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Troleandomycin (TAO for short[1]) is a macrolide antibiotic. It was sold in Italy (branded Triocetin) and Turkey (branded Tekmisin). It is no longer sold in Italy as of 2018.[citation needed]
The drug's mode of action is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis.[2] Troleandomycin is a CYP3A4 inhibitor that may cause drug interactions.[citation needed]
References
- ↑ "Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma". The Journal of Allergy and Clinical Immunology 66 (6): 438–46. December 1980. doi:10.1016/0091-6749(80)90003-2. PMID 6968762.
- ↑ "Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui". Antimicrobial Agents and Chemotherapy 53 (12): 5010–4. December 2009. doi:10.1128/AAC.00817-09. PMID 19738021.
![]() | Original source: https://en.wikipedia.org/wiki/Troleandomycin.
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