Chemistry:Bekanamycin

From HandWiki

Bekanamycin (INN; kanamycin B) is an aminoglycoside antibiotic.[1][2] It was discovered in 1957, along with Kanamycin A,[3] though it was not identified and named until the next year, when it was studied independently.[4] It was later found to be nearly identically efficacious as Kanamycin A, with the only limitation being lower efficacy towards Mycobacterium agents.[5] Animal studies also showed that Bekanamycin was more toxic than Kanamycin A.[6]

References

  1. ↑ "Effects of bekanamycin and dibekacin on the electrical activity of cardiac pacemaker cells". Archives of Medical Research 24 (4): 339–45. 1993. PMID 8118157. 
  2. ↑ PubChem. "Bekanamycin" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/439318. 
  3. ↑ Umezawa, Hamao; Ueda, Masahiro; Maeda, Kenji; Yagishita, Kōki; Kondō, Shinichi; Okami, Yoshirō; Utahara, Ryōzō; Ōsato, Yasuke et al. (1957). "Production and Isolation of a New Antibiotic, Kanamycin". The Journal of Antibiotics, Series A 10 (5): 181–188. doi:10.11554/antibioticsa.10.5_181. https://www.jstage.jst.go.jp/article/antibioticsa/10/5/10_181/_article. 
  4. ↑ Cron, M. J.; Johnson, D. L.; Palermiti, F. M.; Perron, Y.; Taylor, H. D.; Whitehead, D. F.; Hooper, I. R. (1958-02-01). "KANAMYCIN. I. CHARACTERIZATION AND ACID HYDROLYSIS STUDIES" (in en). Journal of the American Chemical Society 80 (3): 752–753. doi:10.1021/ja01536a058. ISSN 0002-7863. https://dx.doi.org/10.1021/ja01536a058. 
  5. ↑ Wakazawa, Tadashi; Sugano, Yoshinori; Abe, Masahiro; Fukatsu, Shunzō; Shohei, Kawaji (1961). "Studies on Kanamycin B. I Isolation of Kanamycin B and Its Chemical and Biological Properties". The Journal of Antibiotics, Series A 14 (4): 180–186. doi:10.11554/antibioticsa.14.4_180. https://www.jstage.jst.go.jp/article/antibioticsa/14/4/14_180/_article. 
  6. ↑ Finegold, Sydney M. (1959-07-01). "Kanamycin" (in en). Archives of Internal Medicine 104 (1): 15. doi:10.1001/archinte.1959.00270070017003. ISSN 0003-9926. http://archinte.jamanetwork.com/article.aspx?doi=10.1001/archinte.1959.00270070017003. 



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