Chemistry:Mephenesin
Mephenesin (INN), also called myanesin,[1][2] is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.[3] Mephenesin was the inspiration for the synthesis of a derivative of 1,3-propanediol, meprobamate, by Bernard Ludwig and Frank Berger,[4] the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in Italy and a few other countries.[5] Its use has largely been replaced by the related drug methocarbamol, which is better absorbed.[6]
Mephenesin may be an NMDA receptor antagonist.[7] Mephenesin was previously used in France as an OTC muscle relaxant called Décontractyl but was taken out of production by Sanofi Aventis and due to a French Health Ministry decree in July 2019.
See also
- Carisoprodol
- Chlorphenesin
- Guaifenesin
- Mephenoxalone
- Methocarbamol
- Prenderol
External links
- "[Severe contact dermatitis caused by mephenesin]". Ann Dermatol Venereol 123 (3): 185–7. 1996. PMID 8761781.
- "Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin". Gen Pharmacol 18 (1): 57–9. 1987. doi:10.1016/0306-3623(87)90170-4. PMID 3557053.
References
- ↑ "Mephenesin Definition & Meaning". https://www.merriam-webster.com/medical/mephenesin.
- ↑ "The mode of action of myanesin". British Journal of Pharmacology and Chemotherapy 2 (4): 241–50. December 1947. doi:10.1111/j.1476-5381.1947.tb00341.x. PMID 19108125.
- ↑ "Mephenesin". MIMS. https://www.mims.com/USA/drug/info/mephenesin/.
- ↑ "The role of serendipity in drug discovery". Dialogues in Clinical Neuroscience 8 (3): 335–44. 2006. doi:10.31887/DCNS.2006.8.3/tban. PMID 17117615.
- ↑ "Mephenesin". Drugs.com. https://www.drugs.com/international/mephenesin.html.
- ↑ Huf, Ernst (1959). "Comparative Plasma Levels of Mephenesin, Mephenesin Carbamate and Methocarbamol". Proceedings of the Society for Experimental Biology and Medicine (Experimental Biology & Medicine) 102 (2): 276–7. doi:10.3181/00379727-102-25218. PMID 14403806. http://ebm.sagepub.com/content/102/2/276.abstract. Retrieved 8 January 2014.
- ↑ "Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice". Iran J Med Sci 38 (2): 116–21. 2013. PMID 23825891.
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