Chemistry:Prenderol

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Prenderol (Diethylpropanediol) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects. It is closely related in structure to meprobamate and numerous other alkyl alcohols and diols with generally comparable activity.[1][2][3][4][5][6]

Synthesis

Treatment of the aldehyde 2-ethylbutyraldehyde with formaldehyde and potassium hydroxide gives a crossed Cannizzaro reaction yielding prenderol.[7]

See also

References

  1. ↑ "Anticonvulsant action of 2-substituted-1,3-propanediols". Proceedings of the Society for Experimental Biology and Medicine (New York, N.Y.) 71 (2): 270–271. June 1949. doi:10.3181/00379727-71-17159. PMID 18134033. 
  2. ↑ "Site of action of 2, 2-diethyl-1,3-propanediol (prenderol) on the central nervous system". The Journal of Pharmacology and Experimental Therapeutics 107 (3): 344–55. March 1953. PMID 13035673. https://jpet.aspetjournals.org/content/107/3/344.short. 
  3. ↑ "Effects of mephenesin and prenderol on intellectual functions of mental patients". Journal of Clinical Psychology 10 (3): 283–5. July 1954. doi:10.1002/1097-4679(195407)10:3<283::aid-jclp2270100322>3.0.co;2-a. PMID 13163224. 
  4. ↑ "Head shaking and nystagmus produced by 2,2-diethyl, 1,3-propanediol (prenderol) in the rat". Archives Internationales de Pharmacodynamie et de Therapie 137: 128–36. May 1962. PMID 13870189. 
  5. ↑ Reyes Q., Aaurelio; Mascetti V., G.; Martinez J., Rolando. Synthesis of polyhydroxylated alcohols. Revista Latinoamericana de Quimica 1984; 15 (1): 29-30. ISSN: 0370-5943.
  6. ↑ "A nitrate ester of sedative alkyl alcohol improves muscle function and structure in a murine model of Duchenne muscular dystrophy". Molecular Pharmaceutics 10 (10): 3862–70. October 2013. doi:10.1021/mp400310r. PMID 23924275. 
  7. ↑ McKusick, B. (1948). "New Compounds. New Compounds as Insect Repellents". Journal of the American Chemical Society 70 (5): 1982–1983. doi:10.1021/ja01185a602. 




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