Chemistry:Zoxazolamine
From HandWiki
Short description: Withdrawn muscle relaxant drug
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| Other names | McN-485 |
| Routes of administration | Oral |
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| Formula | C7H5ClN2O |
| Molar mass | 168.58 g·mol−1 |
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Zoxazolamine (INN, USAN, BAN) (brand name Contrazole, Deflexol, Flexin, Miazol, Uri-Boi, Zoxamine, Zoxine) is a muscle relaxant that is no longer marketed.[1][2] It was synthesized in 1953 and introduced clinically in 1955 but was withdrawn due to hepatotoxicity.[1][2][3] One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine.[3] These drugs activate IKCa channels.[4]
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 48–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA48.
- ↑ 2.0 2.1 Medicinal Chemistry. New Age International. 1 January 2005. pp. 185–. ISBN 978-81-224-1565-0. https://books.google.com/books?id=07g30rxCA0EC&pg=PA185.
- ↑ 3.0 3.1 Forensic Toxicology: Controlled Substances and Dangerous Drugs. Springer Science & Business Media. 6 December 2012. pp. 166–. ISBN 978-1-4684-3444-6. https://books.google.com/books?id=szDnBwAAQBAJ&pg=PA166.
- ↑ Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. 14 August 2008. pp. 996–. ISBN 978-3-540-38916-3. https://books.google.com/books?id=iwwo5gx8aX8C&pg=PA996.
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