Chemistry:Chlormezanone
From HandWiki
Short description: Withdrawn anxiolytic and muscle relaxant
 | |
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Elimination half-life | 40.5 hours |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C11H12ClNO3S |
| Molar mass | 273.73 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Chlormezanone (marketed under the brandname Trancopal or Fenaprim) is a drug used as an anxiolytic and a muscle relaxant.[1]
Its use was discontinued in many countries in 1996 due to rare but serious cases of toxic epidermal necrolysis.[2]
Synthesis
References
- ↑ Drugs Handbook. UK: Palgrave Macmillan. 1997. p. 20. ISBN 978-1-349-13937-8. https://books.google.com/books?id=0_OxCwAAQBAJ&dq=Chlormezanone+anxiolytic&pg=PA20.
- ↑ "Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis". Clinical Reviews in Allergy & Immunology 54 (1): 147–176. February 2018. doi:10.1007/s12016-017-8654-z. PMID 29188475.
- ↑ Surrey AR, "4-metathiazanone derivatives and their preparation", US patent 3082209, issued 1958, assigned to Sterling Drug Inc.
- ↑ "Central Nervous System Depressants. The Preparation of Some 2-Aryl-4-metathiazanones". Journal of the American Chemical Society 80 (13): 3469–3471. 1958. doi:10.1021/ja01546a065.
Further reading
- "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro". Skin Pharmacology and Physiology 18 (3): 132–138. 2005. doi:10.1159/000084910. PMID 15897685.
- "[Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone]". Die Pharmazie 55 (4): 293–296. April 2000. PMID 10798243.
- "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Die Pharmazie 53 (9): 620–624. September 1998. PMID 9770210.
- "[Pharmacokinetics of chlormezanone in healthy volunteers]". Therapie 45 (4): 315–319. 1990. PMID 2399514.
 |  |
