Chemistry:TH-PVP
From HandWiki
Short description: Chemical compound
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| Formula | C19H27NO |
| Molar mass | 285.431 g·mol−1 |
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TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,[1] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.[2][3][4][5][6][7] Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin,[8] but it failed to produce stimulant effects in animals,[9] and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.
See also
References
- ↑ "EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA". http://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf.
- ↑ "Identification and derivatization of selected cathinones by spectroscopic studies". Forensic Science International 266: 416–426. September 2016. doi:10.1016/j.forsciint.2016.06.034. PMID 27423024.
- ↑ "Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances". Journal of Chromatography A 1574: 91–100. November 2018. doi:10.1016/j.chroma.2018.09.006. PMID 30220430.
- ↑ "Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population". Drug Testing and Analysis 10 (3): 539–547. March 2018. doi:10.1002/dta.2232. PMID 28640970.
- ↑ "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone.". Forensic Toxicol 37 (2): 288–307. July 2019. doi:10.1007/s11419-018-00463-w.
- ↑ "New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey". Forensic Science International 294: 113–123. January 2019. doi:10.1016/j.forsciint.2018.11.003. PMID 30502695.
- ↑ "New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study.". Forensic Science International 306: 110002. 24 October 2019. doi:10.1016/j.forsciint.2019.110002. PMID 31864775.
- ↑ "Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology 236 (3): 939–952. March 2019. doi:10.1007/s00213-018-5059-5. PMID 30397775.
- ↑ "Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats". Drug and Alcohol Dependence 199: 50–58. June 2019. doi:10.1016/j.drugalcdep.2019.02.016. PMID 30986635.
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