Chemistry:EDMA
3,4-Ethylenedioxy-N-methylamphetamine (EDMA) is a psychoactive drug of the phenethylamine, amphetamine, and EDxx families.[1][2] It is an analogue of MDMA where the methylenedioxy ring has been replaced by an ethylenedioxy ring.[1][2] EDMA was first synthesized by Alexander Shulgin.[1] In his book PiHKAL, the dose is listed as 150 to 250 mg and the duration as 3 to 5 hours.[1] According to Shulgin, EDMA produces only mild effects that included paresthesia, nystagmus, a dozing state, hypnogogic imagery, and colored letters in the peripheral visual field.[1]
It has been found that EDMA acts as a non-neurotoxic serotonin releasing agent with moderately diminished potency relative to MDMA, and with negligible effects on dopamine release.[2] However, subsequent research found that EMDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) with EC50 values of 117 nM for serotonin release, 325 nM for norepinephrine release, and 597 nM for dopamine release in rat brain synaptosomes.[3] Compared to MDMA, EDMA was about half as potent as a serotonin releaser, 4.5-fold less potent as a norepinephrine releaser, and 8-fold less potent as a dopamine releaser.[3] The activities of the individual enantiomers of EDMA have also been assessed.[3]
See also
- Substituted ethylenedioxyphenethylamine
- 3,4-Ethylenedioxyamphetamine (EDA)
- 3,4-Ethylenedioxymethcathinone (EDMC)
- 3,4-Ethylidenedioxyamphetamine (EIDA)
- 3,4-Isopropylidenedioxyamphetamine (IDA)
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Pihkal: A Chemical Love Story. Transform Press. 1991. ISBN 0-9630096-0-5. http://isomerdesign.com/PiHKAL/read.php?domain=pk&id=110.
- ↑ 2.0 2.1 2.2 "3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine". Pharmacology, Biochemistry, and Behavior 38 (3): 505–512. March 1991. doi:10.1016/0091-3057(91)90005-M. PMID 1829838.
- ↑ 3.0 3.1 3.2 "Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine". Bioorg Med Chem 23 (17): 5574–5579. September 2015. doi:10.1016/j.bmc.2015.07.035. PMID 26233799.
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