Chemistry:3,4-Ethylidenedioxyamphetamine

From HandWiki
Short description: Chemical compound
3,4-Ethylidenedioxyamphetamine
EDA.svg
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  (verify)

3,4-Ethylidenedioxyamphetamine (EIDA) is a substituted derivative of 3,4-methylenedioxyamphetamine (MDA), which was developed by David Nichols and coworkers, in the course of research to determine the bulk tolerance around the benzodioxole portion of the MDA molecule. EIDA was found to produce similar effects to MDA in animals but with less than half the potency, while the isopropylidenedioxy derivative (IPIDA, IDA) did not substitute for MDA and instead had sedative and convulsant effects. This shows limited bulk tolerance at this position and (as with 2C-G-5) makes it likely the activity of EIDA will reside primarily in one enantiomer, although only the racemic mix has been studied as yet.[1][2][3]

Isopropylidenedioxyamphetamine (IDA)

See also

References

  1. "Steric effects of substituents on phenethylamine hallucinogens. 3,4-(Methylenedioxy)amphetamine analogues alkylated on the dioxole ring". Journal of Medicinal Chemistry 22 (10): 1264–7. October 1979. doi:10.1021/jm00196a022. PMID 513074. 
  2. "Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues". Pharmacology, Biochemistry, and Behavior 34 (3): 571–6. November 1989. doi:10.1016/0091-3057(89)90560-1. PMID 2623014. 
  3. "Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives". Chemistry & Biodiversity 3 (3): 326–36. March 2006. doi:10.1002/cbdv.200690035. PMID 17193269.