Biology:Mitochondrial ribosomal protein L39
 Generic protein structure example |
39S ribosomal protein L39, mitochondrial is a protein that in humans is encoded by the MRPL39 gene.[1][2]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.[2]
References
- ↑ "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics 77 (1–2): 65–70. Sep 2001. doi:10.1006/geno.2001.6622. PMID 11543634.
- ↑ 2.0 2.1 "Entrez Gene: MRPL39 mitochondrial ribosomal protein L39". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54148.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 274 (51): 36043–51. 2000. doi:10.1074/jbc.274.51.36043. PMID 10593885.
- "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)". Gene 261 (2): 229–34. 2001. doi:10.1016/S0378-1119(00)00504-7. PMID 11167009.
- O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics 81 (5): 468–80. 2003. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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