Biology:Mitochondrial ribosomal protein L12
 Generic protein structure example |
39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.[1][2][3]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.[3]
References
- ↑ "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein". J Biol Chem 271 (19): 11468–76. Jun 1996. doi:10.1074/jbc.271.19.11468. PMID 8626705.
- ↑ "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12". Genomics 41 (3): 453–7. Jul 1997. doi:10.1006/geno.1997.4691. PMID 9169145.
- ↑ 3.0 3.1 "Entrez Gene: MRPL12 mitochondrial ribosomal protein L12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6182.
Further reading
- "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle.". Biochemistry 38 (50): 16569–77. 2000. doi:10.1021/bi991543s. PMID 10600119.
- "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1–2): 65–70. 2001. doi:10.1006/geno.2001.6622. PMID 11543634.
- "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958–69. 2001. doi:10.1074/jbc.M106510200. PMID 11551941.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. 2003. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.". J. Biol. Chem. 282 (17): 12610–8. 2007. doi:10.1074/jbc.M700461200. PMID 17337445.
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