Biology:CXCL15

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Short description: Mammalian protein found in Mus musculus


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,[1] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.[2] The gene for CXCL15 is found on mouse chromosome 5.

References

  1. "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol 162 (9): 5490–7. 1999. doi:10.4049/jimmunol.162.9.5490. PMID 10228029. 
  2. "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem 55 (5): 515–24. 2007. doi:10.1369/jhc.6A7121.2007. PMID 17242461.