Biology:Pimelyl-(acyl-carrier protein) methyl ester esterase
From HandWiki
| Pimelyl-[acyl-carrier protein] methyl ester esterase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.1.85 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme Pimelyl-[acyl-carrier protein] methyl ester esterase (EC 3.1.1.85, BioH; systematic name pimelyl-[acyl-carrier protein] methyl ester hydrolase[1][2][3][4] catalyses the reaction
- pimelyl-[acyl-carrier protein] methyl ester + H2O [math]\displaystyle{ \rightleftharpoons }[/math] pimelyl-[acyl-carrier protein] + methanol
This enzyme takes part in biotin biosynthesis in Gram-negative bacteria.
References
- ↑ "Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli". The Journal of Biological Chemistry 278 (28): 26039–45. July 2003. doi:10.1074/jbc.M303867200. PMID 12732651.
- ↑ "To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli". Molecular Microbiology 19 (3): 645–7. February 1996. doi:10.1046/j.1365-2958.1996.t01-4-442924.x. PMID 8830257.
- ↑ "Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway". FEBS Letters 513 (2-3): 299–304. February 2002. doi:10.1016/s0014-5793(02)02342-6. PMID 11904168.
- ↑ "Biotin synthesis begins by hijacking the fatty acid synthetic pathway". Nature Chemical Biology 6 (9): 682–8. September 2010. doi:10.1038/nchembio.420. PMID 20693992.
External links
- Pimelyl-(acyl-carrier+protein)+methyl+ester+esterase at the US National Library of Medicine Medical Subject Headings (MeSH)
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