Biology:Novel coronavirus (2019-nCoV)

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Novel coronavirus (2019-nCoV)
Virus classification e
Missing taxonomy template (fix): Incertae sedis/Betacoronavirus
Virus:
Novel coronavirus (2019-nCoV)
Wuhan China.png
Wuhan, China; primary location of the only recorded outbreak
Synonyms
  • Wuhan seafood market pneumonia virus
  • Wuhan pneumonia
  • Wuhan coronavirus
Genomic information
NCBI genome IDMN908947
Genome size30473 bp
Year of completion2020

Novel coronavirus, denoted 2019-nCoV by the WHO[1][2] and also known as Wuhan coronavirus, Wuhan seafood market pneumonia virus and Wuhan pneumonia,[3] is a positive-sense, single-stranded RNA coronavirus first reported in 2019. The virus was genomically sequenced after nucleic acid testing on a positive patient sample in a patient with pneumonia during the 2019–2020 Wuhan pneumonia outbreak.[4][5][6]

On 20 January 2020, human-to-human transmission was confirmed in Guangdong province, China , according to Zhong Nanshan, head of the health commission team investigating the outbreak.[7] No specific treatment for the new virus is currently available, but existing anti-virals could be repurposed.[8]

The virus has spread to Bangkok, Tokyo, South Korea , Beijing, Shanghai, Guangdong Province, Taiwan, and Washington State in the United States. There have been 6 fatalities and 317 known cases.[9]

Phylogenetics

Sequences of Wuhan betacoronavirus show similarities to betacoronaviruses found in bats; however, the virus is genetically distinct from other coronaviruses such as Severe acute respiratory syndrome-related coronavirus (SARS) and Middle East respiratory syndrome-related coronavirus (MERS).[6] Like SARS-CoV, it is a member of Beta-CoV lineage B.[10]

Five genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the China CDC National Institute for Viral Disease Control and Prevention, Institute of Pathogen Biology, and Wuhan Jinyintan Hospital.[6][11][12] Its RNA sequence is approximately 30 kbp in length.[6]

See also

Diseases caused by genetically similar viruses:

References

  1. ↑ "Surveillance case definitions for human infection with novel coronavirus (nCoV)" (in en). https://www.who.int/publications-detail/surveillance-case-definitions-for-human-infection-with-novel-coronavirus-(ncov). 
  2. ↑ "Novel coronavirus (2019-nCoV), Wuhan, China". cdc.gov. 10 January 2020. https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html. Retrieved 16 January 2020. 
  3. ↑ Zhang, Y.-Z. (12 January 2020) (in en). Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome. Bethesda MD. https://www.ncbi.nlm.nih.gov/nuccore/MN908947. Retrieved 13 January 2020. 
  4. ↑ "中国疾病预防控制中心". http://www.chinacdc.cn/dfdt/201912/t20191226_209404.html. 
  5. ↑ "New-type coronavirus causes pneumonia in Wuhan: expert – Xinhua | English.news.cn". http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm. 
  6. ↑ 6.0 6.1 6.2 6.3 "CoV2020". https://platform.gisaid.org/epi3/start/CoV2020. 
  7. ↑ "China confirms human-to-human transmission of new coronavirus". CBC News. Jan 20, 2020. https://www.cbc.ca/news/health/coronavirus-human-to-human-1.5433187. 
  8. ↑ "WHO says new China coronavirus could spread, warns hospitals worldwide" (in en). Reuters. 2020-01-14. https://www.reuters.com/article/us-china-health-pneumonia-who-idUSKBN1ZD16J. 
  9. ↑ "Wuhan virus: China reports fourth death in pneumonia outbreak; 15 medical workers infected". https://www.straitstimes.com/asia/east-asia/china-says-fourth-person-dies-in-wuhan-pneumonia-outbreak. Retrieved 20 January 2020. 
  10. ↑ "Phylogeny of SARS-like betacoronaviruses". https://nextstrain.org/groups/blab/sars-like-cov. Retrieved 18 January 2020. 
  11. ↑ "Initial genome release of novel coronavirus" (in en-US). 11 January 2020. http://virological.org/t/initial-genome-release-of-novel-coronavirus/319. 
  12. ↑ (in en-US) Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome. 2020-01-17. http://www.ncbi.nlm.nih.gov/nuccore/MN908947.3. 

External links

Wikidata ☰ Q82069695 entry




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