Biology:MRPS26
 Generic protein structure example |
28S ribosomal protein S26, mitochondrial is a protein that in humans is encoded by the MRPS26 gene.[1][2]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene.[2]
References
- ↑ "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics 77 (1–2): 65–70. Sep 2001. doi:10.1006/geno.2001.6622. PMID 11543634.
- ↑ 2.0 2.1 "Entrez Gene: MRPS26 mitochondrial ribosomal protein S26". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64949.
Further reading
- "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828–36. 1999. doi:10.1074/jbc.273.52.34828. PMID 9857009.
- "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present.". J. Biol. Chem. 276 (22): 19363–74. 2001. doi:10.1074/jbc.M100727200. PMID 11279123.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. 2003. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
- "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. 2003. PMID 12747765.
- "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA.". Int. J. Cancer 111 (6): 900–9. 2004. doi:10.1002/ijc.20358. PMID 15300802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9BYN8 (28S ribosomal protein S26, mitochondrial) at the PDBe-KB.
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