Biology:Phosphoserine phosphatase
From HandWiki
| phosphoserine phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.3 | ||||||||
| CAS number | 9025-73-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme phosphoserine phosphatase (EC 3.1.3.3) catalyzes the reaction
- O-phospho-L(or D)-serine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] L(or D)-serine + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is O-phosphoserine phosphohydrolase. This enzyme participates in glycine, serine and threonine metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1F5S, 1J97, 1L7M, 1L7N, 1L7O, 1L7P, 1L8L, 1L8O, 1NNL, 2J6Y, 2J6Z, and 2J70.
References
- "The enzymatic exchange of L-serine with O-phospho-L-serine catalyzed by a specific phosphatase". J. Biol. Chem. '234 (4): 849–53. 1959. PMID 13654276.
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
- "Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase". J. Biol. Chem. 234 (1): 113–121. 1959. PMID 13610904.
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