Biology:P53 p63 p73 family
The p53 p63 p73 family is a family of tumor suppressor genes.[1][2]
This gene family codes the proteins:
They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis.[3]
Evolution
P53, p63, and p73 have similar features in their gene structures and functions but have also diverged evolutionarily. The p53 family evolved from an ancestor gene in unicellular life.[4] The ancestor gene functioned in germ line DNA protection early invertebrates.[5] In invertebrates, the ancestor gene resembled p63/p73 as it contained the sterile alpha motif (SAM) domain.[6] P53 diverged from p63/p73 with a gene duplication in the cartilaginous fish.[7] P63 and p73 differentiated from each other in bony fish.[7] In vertebrates, p53 began the role of protecting the somatic cells and acting as a tumor suppressor.[8][7]
References
- ↑ "The p53/p63/p73 family of transcription factors: overlapping and distinct functions". Journal of Cell Science 113 ( Pt 10) (10): 1661–1670. May 2000. doi:10.1242/jcs.113.10.1661. PMID 10769197.
- ↑ The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans. Academic Press. 2007. pp. 350–. ISBN 978-0-12-373657-4. https://books.google.com/books?id=4rGOLEOC4mEC&pg=PA350. Retrieved 23 December 2010.
- ↑ "Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease". Clinical and Experimental Dermatology 33 (5): 634–640. August 2008. doi:10.1111/j.1365-2230.2008.02851.x. PMID 18627398.
- ↑ "Early diversification and complex evolutionary history of the p53 tumor suppressor gene family". Development Genes and Evolution 217 (11–12): 801–806. December 2007. doi:10.1007/s00427-007-0185-9. PMID 17924139.
- ↑ Rutherford, Suzannah, ed (September 2007). "The p53 tumor suppressor-like protein nvp63 mediates selective germ cell death in the sea anemone Nematostella vectensis". PLOS ONE 2 (9): e782. doi:10.1371/journal.pone.0000782. PMID 17848985. Bibcode: 2007PLoSO...2..782P.
- ↑ "Phylogeny and function of the invertebrate p53 superfamily". Cold Spring Harbor Perspectives in Biology 2 (7): a001131. July 2010. doi:10.1101/cshperspect.a001131. PMID 20595397.
- ↑ 7.0 7.1 7.2 "The origins and evolution of the p53 family of genes". Cold Spring Harbor Perspectives in Biology 2 (6): a001198. June 2010. doi:10.1101/cshperspect.a001198. PMID 20516129.
- ↑ "p53: 800 million years of evolution and 40 years of discovery". Nature Reviews. Cancer 20 (8): 471–480. August 2020. doi:10.1038/s41568-020-0262-1. PMID 32404993.
 |  |
