Biology:KLF6

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.

It is a tumor suppressor gene.

Function

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.

Interactions

KLF6 has been shown to interact with Sp1 transcription factor.

See also

• Kruppel-like factors

Further reading

• "Krüppel cripples prostate cancer: KLF6 progress and prospects". The American Journal of Pathology 162 (4): 1047–52. Apr 2003. doi:10.1016/S0002-9440(10)63901-6. PMID 12651597. 
• "Identification of Bcd, a novel proto-oncogene expressed in B-cells". Oncogene 13 (12): 2623–30. Dec 1996. PMID 9000136. 
• "A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene". The Journal of Biological Chemistry 272 (14): 9573–80. Apr 1997. doi:10.1074/jbc.272.14.9573. PMID 9083102. 
• "Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter". Journal of Biochemistry 124 (2): 389–95. Aug 1998. doi:10.1093/oxfordjournals.jbchem.a022124. PMID 9685731. 
• "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis". Proceedings of the National Academy of Sciences of the United States of America 95 (16): 9500–5. Aug 1998. doi:10.1073/pnas.95.16.9500. PMID 9689109. Bibcode: 1998PNAS...95.9500R. 
• "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact". FEBS Letters 473 (1): 95–100. May 2000. doi:10.1016/S0014-5793(00)01468-X. PMID 10802067. 
• "KLF6, a candidate tumor suppressor gene mutated in prostate cancer". Science 294 (5551): 2563–6. Dec 2001. doi:10.1126/science.1066326. PMID 11752579. Bibcode: 2001Sci...294.2563N. 
• "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood 100 (12): 4001–10. Dec 2002. doi:10.1182/blood.V100.12.4001. PMID 12433697. 
• "[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]". AI Zheng = Aizheng = Chinese Journal of Cancer 21 (10): 1047–50. Oct 2002. PMID 12508640. 
• "Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6". The Journal of Biological Chemistry 278 (17): 14812–9. Apr 2003. doi:10.1074/jbc.M300787200. PMID 12590140. 
• "Deletion, mutation, and loss of expression of KLF6 in human prostate cancer". The American Journal of Pathology 162 (4): 1349–54. Apr 2003. doi:10.1016/S0002-9440(10)63930-2. PMID 12651626. 
• "KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas". International Journal of Cancer 105 (5): 625–9. Jul 2003. doi:10.1002/ijc.11123. PMID 12740910. 
• "Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene". Plastic and Reconstructive Surgery 111 (7): 2133–9. Jun 2003. doi:10.1097/01.PRS.0000060531.98180.32. PMID 12794452. 
• "Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer". Gastroenterology 126 (4): 1090–103. Apr 2004. doi:10.1053/j.gastro.2004.01.005. PMID 15057748. 
• "Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6". Oncogene 23 (29): 5077–83. Jun 2004. doi:10.1038/sj.onc.1207662. PMID 15064720. 
• "Gene expression profiling predicts clinical outcome of prostate cancer". The Journal of Clinical Investigation 113 (6): 913–23. Mar 2004. doi:10.1172/JCI20032. PMID 15067324. 
• "Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53". Endocrinology 145 (8): 3769–77. Aug 2004. doi:10.1210/en.2004-0173. PMID 15131018. 

External links

• KLF6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.