Biology:CCL24
| chemokine (C-C motif) ligand 24 | |
|---|---|
| Identifiers | |
| Symbol | CCL24 |
| Alt. symbols | SCYA24, Ckb-6, MPIF-2, eotaxin-2 |
| NCBI gene | 6369 |
| HGNC | 10623 |
| OMIM | 602495 |
| PDB | 1EIG |
| RefSeq | NM_002991 |
| UniProt | O00175 |
| Other data | |
| Locus | Chr. 7 q11.23 |
Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is a protein that in humans is encoded by the CCL24 gene.[1] This gene is located on human chromosome 7.[2]
Function
CCL24 is a small cytokine belonging to the CC chemokine family. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils.[3] This chemokine is also strongly chemotactic for resting T lymphocytes and slightly chemotactic for neutrophils.[1]
Clinical significance
Elevated levels of eotaxin-2 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[4]
References
- ↑ 1.0 1.1 "Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors". J. Exp. Med. 185 (7): 1163–72. April 1997. doi:10.1084/jem.185.7.1163. PMID 9104803.
- ↑ "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. July 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- ↑ "Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils". J. Leukoc. Biol. 62 (5): 667–75. November 1997. doi:10.1002/jlb.62.5.667. PMID 9365122.
- ↑ "Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease". Allergy 65 (3): 338–346. October 2009. doi:10.1111/j.1398-9995.2009.02158.x. PMID 19796209.
 |  |
