Biology:40S ribosomal protein S13
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.[1][2][3]
Function
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]
Interactions
RPS13 has been shown to interact with PDCD4.[4]
References
- ↑ "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res 21 (12): 2945. Aug 1993. doi:10.1093/nar/21.12.2945. PMID 8332508.
- ↑ "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. Aug 1998. doi:10.1101/gr.8.5.509. PMID 9582194.
- ↑ 3.0 3.1 "Entrez Gene: RPS13 ribosomal protein S13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6207.
- ↑ "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. April 2002. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
Further reading
- "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009.
- "The primary structure of rat ribosomal protein S13.". Biochem. Biophys. Res. Commun. 171 (2): 519–24. 1990. doi:10.1016/0006-291X(90)91176-S. PMID 2403345.
- "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. 1996. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene.". Biochem. Biophys. Res. Commun. 228 (2): 371–4. 1996. doi:10.1006/bbrc.1996.1668. PMID 8920921.
- "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14.". Cytogenet. Cell Genet. 92 (1–2): 103–7. 2001. doi:10.1159/000056877. PMID 11306805.
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Up-regulation of PDCD4 in senescent human diploid fibroblasts.". Biochem. Biophys. Res. Commun. 293 (1): 617–21. 2002. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13.". Mol. Cell. Biol. 23 (15): 5320–30. 2003. doi:10.1128/MCB.23.15.5320-5330.2003. PMID 12861018.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
- "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis.". Exp. Cell Res. 296 (2): 337–46. 2004. doi:10.1016/j.yexcr.2004.02.009. PMID 15149863.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455.
- "Human ribosomal protein S13: cloning, expression, refolding, and structural stability.". Biochim. Biophys. Acta 1747 (1): 93–7. 2005. doi:10.1016/j.bbapap.2004.10.001. PMID 15680243.
- "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. 2005. doi:10.1110/ps.041293005. PMID 15883184.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
External links
- Overview of all the structural information available in the PDB for UniProt: P62277 (40S ribosomal protein S13) at the PDBe-KB.
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