Biology:6-phosphofructo-2-kinase
| 6-phosphofructo-2-kinase | |||||||||
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 6-phosphofructo-2-kinase dimer, Human heart | |||||||||
| Identifiers | |||||||||
| EC number | 2.7.1.105 | ||||||||
| CAS number | 78689-77-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| 6PF2K | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | |||||||||
| Identifiers | |||||||||
| Symbol | 6PF2K | ||||||||
| Pfam | PF01591 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR013079 | ||||||||
| PROSITE | PDOC00158 | ||||||||
| SCOP2 | 1bif / SCOPe / SUPFAM | ||||||||
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Thus, the two substrates of this enzyme are ATP and beta-D-fructose 6-phosphate, whereas its two products are ADP and beta-D-fructose 2,6-bisphosphate.
The systematic name of this enzyme class is ATP:beta-D-fructose-6-phosphate 2-phosphotransferase. Other names in common use include phosphofructokinase 2, 6-phosphofructose 2-kinase, 6-phosphofructo-2-kinase (phosphorylating), fructose 6-phosphate 2-kinase, and ATP:D-fructose-6-phosphate 2-phosphotransferase. This enzyme participates in fructose and mannose metabolism. The enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver, kidney and heart. In mammals, several genes often encode different isoforms, each of which differs in its tissue distribution and enzymatic activity.[1] The family described here bears a resemblance to the ATP-driven phospho-fructokinases, however, they share little sequence similarity, although a few residues seem key to their interaction with fructose 6-phosphate.[2]
References
- ↑ "Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)". Eur. J. Biochem. 254 (1): 103–10. May 1998. doi:10.1046/j.1432-1327.1998.2540103.x. PMID 9652401.
- ↑ "An essential methionine residue involved in substrate binding by phosphofructokinases". Biochem. Biophys. Res. Commun. 250 (2): 466–8. September 1998. doi:10.1006/bbrc.1998.9311. PMID 9753654.
- "Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose 6-phosphate and ATP". Biochem. Biophys. Res. Commun. 101 (3): 1078–84. 1981. doi:10.1016/0006-291X(81)91859-3. PMID 6458291.
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