Biology:60S ribosomal protein L10

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Interactions

RPL10 has been shown to interact with YES1.

Further reading

• "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. 1996. doi:10.1139/o95-101. PMID 8722009. 
• "Identification and characterization of a new gene in the human Xq28 region". Hum. Mol. Genet. 1 (4): 269–73. 1993. doi:10.1093/hmg/1.4.269. PMID 1303197. 
• "The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor". Hum. Genet. 90 (1–2): 144–6. 1992. doi:10.1007/bf00210759. PMID 1330878. 
• "Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28". Hum. Mol. Genet. 1 (7): 529–33. 1993. doi:10.1093/hmg/1.7.529. PMID 1339145. 
• "cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene". Biochem. Biophys. Res. Commun. 184 (3): 1165–72. 1992. doi:10.1016/S0006-291X(05)80005-1. PMID 1534224. 
• "The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells". Nucleic Acids Res. 19 (20): 5763–9. 1991. doi:10.1093/nar/19.20.5763. PMID 1658743. 
• "Construction of a human full-length cDNA bank". Gene 150 (2): 243–50. 1995. doi:10.1016/0378-1119(94)90433-2. PMID 7821789. 
• "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. 1994. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Isolation and characterization of the QM promoter". Nucleic Acids Res. 24 (11): 2158–65. 1996. doi:10.1093/nar/24.11.2158. PMID 8668549. 
• "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum. Mol. Genet. 5 (5): 659–68. 1997. doi:10.1093/hmg/5.5.659. PMID 8733135. 
• "The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor". Biochem. Biophys. Res. Commun. 225 (3): 952–6. 1996. doi:10.1006/bbrc.1996.1277. PMID 8780716. 
• "QM is a novel zinc-binding transcription regulatory protein: its binding to c-Jun is regulated by zinc ions and phosphorylation by protein kinase C". Biochem. Biophys. Res. Commun. 230 (2): 331–4. 1997. doi:10.1006/bbrc.1996.5955. PMID 9016777. 
• "The QM protein associates with ribosomes in the rough endoplasmic reticulum". Biochemistry 36 (27): 8224–30. 1997. doi:10.1021/bi970288d. PMID 9204867. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm". J. Cell. Biochem. 68 (2): 281–5. 1998. doi:10.1002/(SICI)1097-4644(19980201)68:2<281::AID-JCB14>3.0.CO;2-I. PMID 9443083. 
• "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.