Biology:Bone morphogenetic protein 8B
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Bone morphogenetic protein 8B is a protein that in humans is encoded by the BMP8B gene.[1][2][3]
The protein encoded by this gene is a member of the TGF-β superfamily. It has close sequence homology to BMP7 and BMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in the hippocampus of murine embryos.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.[3]
References
- ↑ "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem 267 (35): 25220–7. Jan 1993. doi:10.1016/S0021-9258(19)74028-9. PMID 1460021.
- ↑ "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics 40 (1): 196–8. Jun 1997. doi:10.1006/geno.1996.4533. PMID 9070944.
- ↑ 3.0 3.1 "Entrez Gene: BMP8B bone morphogenetic protein 8b (osteogenic protein 2)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=656.
Further reading
- Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
- "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas". Oncogene 25 (18): 2666–73. 2006. doi:10.1038/sj.onc.1209297. PMID 16314833.
- Saito T; Ji G; Shinzawa H et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C". Biochem. Biophys. Res. Commun. 317 (2): 335–41. doi:10.1016/j.bbrc.2004.03.056. PMID 15063762.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7858–62. 2001. doi:10.1073/pnas.151242798. PMID 11427739. Bibcode: 2001PNAS...98.7858Y.
- Ying Y; Liu XM; Marble A et al. (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse". Mol. Endocrinol. 14 (7): 1053–63. doi:10.1210/mend.14.7.0479. PMID 10894154.
- Auffray C; Behar G; Bois F et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III 318 (2): 263–72. PMID 7757816.
External links
- Human BMP8B genome location and BMP8B gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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