Biology:C-c motif chemokine ligand 27

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Short description: Mammalian protein found in Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example
chemokine (C-C motif) ligand 27
Identifiers
SymbolCCL27
Alt. symbolsSCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gene10850
HGNC10626
OMIM604833
RefSeqNM_006664
UniProtQ9Y4X3
Other data
LocusChr. 9 q13

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [1]

Function

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[2][3] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[4] The gene for CCL27 is located on human chromosome 9.[5] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

References

  1. ↑ "Entrez Gene: C-C motif chemokine ligand 27". https://www.ncbi.nlm.nih.gov/gene/10850. 
  2. ↑ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
  3. ↑ "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine 8 (2): 157–65. February 2002. doi:10.1038/nm0202-157. PMID 11821900. 
  4. ↑ "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology 164 (7): 3465–70. April 2000. doi:10.4049/jimmunol.164.7.3465. PMID 10725697. 
  5. ↑ "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters 460 (3): 544–8. November 1999. doi:10.1016/s0014-5793(99)01406-4. PMID 10556532. 

Further reading

  • "New avenues for anti-inflammatory therapy". Nature Medicine 8 (2): 117–8. February 2002. doi:10.1038/nm0202-117. PMID 11821893. 
  • "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris". The Journal of Allergy and Clinical Immunology 111 (3): 592–7. March 2003. doi:10.1067/mai.2003.114. PMID 12642842. 
  • "Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis". The Journal of Allergy and Clinical Immunology 113 (2): 334–40. February 2004. doi:10.1016/j.jaci.2003.12.007. PMID 14767451. 
  • "TARC augments TNF-alpha-induced CTACK production in keratinocytes". Experimental Dermatology 13 (9): 551–7. September 2004. doi:10.1111/j.0906-6705.2004.00202.x. PMID 15335355. 
  • "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus". The Journal of Biological Chemistry 279 (50): 51775–82. December 2004. doi:10.1074/jbc.M409868200. PMID 15466853. 
  • "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB". Cytokine 29 (2): 49–55. January 2005. doi:10.1016/j.cyto.2004.09.008. PMID 15598438. 
  • "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure". Experimental Dermatology 14 (2): 109–16. February 2005. doi:10.1111/j.0906-6705.2005.00226.x. PMID 15679580. 
  • "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27". Experimental Dermatology 15 (2): 95–100. February 2006. doi:10.1111/j.1600-0625.2005.00390.x. PMID 16433680. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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