Biology:CCBP2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.[1][2][3]
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[3]
References
- ↑ "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol 16 (10): 1249–56. Dec 1997. doi:10.1089/dna.1997.16.1249. PMID 9364936.
- ↑ "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". J Biol Chem 272 (51): 32078–83. Jan 1998. doi:10.1074/jbc.272.51.32078. PMID 9405404.
- ↑ 3.0 3.1 "Entrez Gene: CCBP2 chemokine binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1238.
Further reading
- "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.". J. Biol. Chem. 272 (19): 12495–504. 1997. doi:10.1074/jbc.272.19.12495. PMID 9139699.
- "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity.". J. Biol. Chem. 274 (25): 17478–83. 1999. doi:10.1074/jbc.274.25.17478. PMID 10364178.
- "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3–4): 265–8. 2000. doi:10.1159/000015443. PMID 10702689.
- "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.". J. Immunol. 164 (6): 2851–6. 2000. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
- "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.". J. Immunol. 164 (7): 3460–4. 2000. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
- "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).". J. Immunol. 164 (7): 3465–70. 2000. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
- "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).". J. Biol. Chem. 275 (29): 22313–23. 2000. doi:10.1074/jbc.M001461200. PMID 10781587.
- "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.". Am. J. Pathol. 158 (3): 867–77. 2001. doi:10.1016/s0002-9440(10)64035-7. PMID 11238036.
- "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.". Nat. Med. 8 (2): 157–65. 2002. doi:10.1038/nm0202-157. PMID 11821900.
- "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking.". Blood 101 (5): 1677–82. 2003. doi:10.1182/blood-2002-07-2348. PMID 12406880.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.". J. Immunol. 170 (5): 2279–82. 2003. doi:10.4049/jimmunol.170.5.2279. PMID 12594248.
- "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.". J. Clin. Invest. 111 (7): 1001–10. 2003. doi:10.1172/JCI17244. PMID 12671049.
- "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.". J. Biol. Chem. 279 (24): 25590–7. 2004. doi:10.1074/jbc.M400363200. PMID 15084596.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes.". J. Virol. 79 (15): 9618–24. 2005. doi:10.1128/JVI.79.15.9618-9624.2005. PMID 16014924.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- Human ACKR2 genome location and ACKR2 gene details page in the UCSC Genome Browser.
- Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
- Human CCR9 genome location and CCR9 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
