Biology:Exodeoxyribonuclease III

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Exodeoxyribonuclease III
Identifiers
EC number3.1.11.2
CAS number9037-44-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Exodeoxyribonuclease III (EC 3.1.11.2, Escherichia coli exonuclease III, E. coli exonuclease III, endoribonuclease III) is an enzyme[1][2][3] that catalyses the following reaction

Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates

This enzyme has a preference for double-stranded DNA.

References

  1. "Properties of deoxyribonuclease 3 from mammalian tissues". The Journal of Biological Chemistry 244 (18): 5014–9. September 1969. PMID 5824576. 
  2. "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity". The Journal of Biological Chemistry 239: 242–50. January 1964. PMID 14114850. 
  3. "A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity". The Journal of Biological Chemistry 239: 251–8. January 1964. PMID 14114851. 

External links