Biology:Fyn-related kinase
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[1][2]
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[2]
Interactions
FRK has been shown to interact with retinoblastoma protein.[3]
References
- ↑ "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene 138 (1–2): 247–51. April 1994. doi:10.1016/0378-1119(94)90817-6. PMID 7510261.
- ↑ 2.0 2.1 "Entrez Gene: FRK fyn-related kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2444.
- ↑ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. (UNITED STATES) 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.
Further reading
- "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6–10): 409–19. 2003. doi:10.3727/096504003108748438. PMID 12725532.
- "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.". Cancer Res. 55 (18): 3969–72. 1995. PMID 7664264.
- "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.". Cell Growth Differ. 5 (12): 1347–55. 1995. PMID 7696183.
- "Novel protein kinases expressed in human breast cancer.". Int. J. Cancer 54 (4): 571–7. 1993. doi:10.1002/ijc.2910540409. PMID 8099900.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.". Int. J. Cancer 104 (2): 139–46. 2003. doi:10.1002/ijc.10925. PMID 12569567.
- "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.". Neurosci. Lett. 360 (1–2): 109–11. 2004. doi:10.1016/j.neulet.2004.02.046. PMID 15082191.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell. Proteomics 4 (9): 1240–50. 2005. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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