Biology:DDR1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.

Function

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein. In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics 25 (1): 309–11. Jan 1995. doi:10.1016/0888-7543(95)80144-B. PMID 7774938. 
• "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics 25 (2): 584–7. Jan 1995. doi:10.1016/0888-7543(95)80065-T. PMID 7789998. 
• "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Annals of Surgical Oncology 1 (1): 18–27. Jan 1994. doi:10.1007/BF02303537. PMID 7834423. 
• "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth & Differentiation 5 (11): 1173–83. Nov 1994. PMID 7848919. 
• "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Molecular and Cellular Biology 14 (4): 2713–21. Apr 1994. doi:10.1128/MCB.14.4.2713. PMID 8139570. 
• "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". The Journal of Biological Chemistry 268 (32): 24290–5. Nov 1993. doi:10.1016/S0021-9258(20)80524-9. PMID 8226977. 
• "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene 9 (1): 211–9. Jan 1994. PMID 8302582. 
• "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proceedings of the National Academy of Sciences of the United States of America 90 (12): 5677–81. Jun 1993. doi:10.1073/pnas.90.12.5677. PMID 8390675. Bibcode: 1993PNAS...90.5677J. 
• "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene 12 (7): 1469–77. Apr 1996. PMID 8622863. 
• "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Human Genetics 98 (1): 12–5. Jul 1996. doi:10.1007/s004390050152. PMID 8682498. 
• "The genomic structure of discoidin receptor tyrosine kinase". Genome Research 6 (7): 620–7. Jul 1996. doi:10.1101/gr.6.7.620. PMID 8796349. 
• "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Letters 398 (2–3): 165–9. Dec 1996. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099. 
• "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology 65 (4): 195–203. 1998. doi:10.1159/000164123. PMID 9396043. 
• "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology 139 (3): 852–8. Mar 1998. doi:10.1210/endo.139.3.5791. PMID 9492013. 
• "The discoidin domain receptor tyrosine kinases are activated by collagen". Molecular Cell 1 (1): 13–23. Dec 1997. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899. 
• "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell 1 (1): 25–34. Dec 1997. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900. 
• "Discoidin domain receptor 1 is activated independently of beta(1) integrin". The Journal of Biological Chemistry 275 (8): 5779–84. Feb 2000. doi:10.1074/jbc.275.8.5779. PMID 10681566. 
• "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB Journal 14 (7): 973–81. May 2000. doi:10.1096/fasebj.14.7.973. PMID 10783152. 
• "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery 47 (6): 1400–9. Dec 2000. doi:10.1097/00006123-200012000-00028. PMID 11126911. 
• "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea". Experimental Eye Research 72 (1): 87–92. Jan 2001. doi:10.1006/exer.2000.0932. PMID 11133186. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.