Biology:Feline sarcoma oncogene
 Generic protein structure example |
Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.[1][2] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.[3]
Function
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[2]
Interactions
Feline sarcoma oncogene has been shown to interact with BCAR1[4] and BCR gene.[5][6]
References
- ↑ "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research 19 (15): 4311. Aug 1991. doi:10.1093/nar/19.15.4311. PMID 1870997.
- ↑ 2.0 2.1 "Entrez Gene: FES feline sarcoma oncogene". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242.
- ↑ "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience 17: 861–75. 2012. doi:10.2741/3961. PMID 22201778.
- ↑ "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry 272 (4): 2104–9. Jan 1997. doi:10.1074/jbc.272.4.2104. PMID 8999909.
- ↑ "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research 60 (4): 1097–103. Feb 2000. PMID 10706130.
- ↑ "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology 15 (2): 835–42. Feb 1995. doi:10.1128/MCB.15.2.835. PMID 7529874.
Further reading
- "The c-Fes family of protein-tyrosine kinases". Critical Reviews in Oncogenesis 9 (1): 43–62. 1998. doi:10.1615/critrevoncog.v9.i1.40. PMID 9754447.
- "IL-4/IL-13 signaling beyond JAK/STAT". The Journal of Allergy and Clinical Immunology 105 (6 Pt 1): 1063–70. Jun 2000. doi:10.1067/mai.2000.107604. PMID 10856136.
- "Closing in on the biological functions of Fps/Fes and Fer". Nature Reviews Molecular Cell Biology 3 (4): 278–89. Apr 2002. doi:10.1038/nrm783. PMID 11994747.
External links
- Overview of all the structural information available in the PDB for UniProt: P07332 (Tyrosine-protein kinase Fes/Fps) at the PDBe-KB.
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