Biology:TXK (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.[1][2][3]
References
- ↑ "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12". Hum Mol Genet 3 (6): 897–901. Nov 1994. doi:10.1093/hmg/3.6.897. PMID 7951233.
- ↑ "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics 22 (2): 431–6. Jan 1995. doi:10.1006/geno.1994.1405. PMID 7528718.
- ↑ "Entrez Gene: TXK TXK tyrosine kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7294.
Further reading
- "Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.". Clinical Medicine & Research 4 (2): 147–51. 2006. doi:10.3121/cmr.4.2.147. PMID 16809408.
- "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene.". Oncogene 12 (4): 937–42. 1996. PMID 8632917.
- "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.". J. Biol. Chem. 271 (33): 19641–4. 1996. doi:10.1074/jbc.271.33.19641. PMID 8702662.
- "Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.". Immunity 6 (2): 155–64. 1997. doi:10.1016/S1074-7613(00)80422-7. PMID 9047237.
- "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.". Biochem. Biophys. Res. Commun. 252 (1): 14–9. 1998. doi:10.1006/bbrc.1998.9559. PMID 9813138.
- "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657–68. 2000. doi:10.1084/jem.190.11.1657. PMID 10587356.
- "Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.". J. Biol. Chem. 275 (6): 3835–40. 2000. doi:10.1074/jbc.275.6.3835. PMID 10660534.
- "Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.". BMC Immunol. 2: 3. 2004. doi:10.1186/1471-2172-2-3. PMID 11353545.
- "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.". J. Immunol. 168 (5): 2365–70. 2002. doi:10.4049/jimmunol.168.5.2365. PMID 11859127.
- "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.". Biol. Pharm. Bull. 25 (6): 718–21. 2002. doi:10.1248/bpb.25.718. PMID 12081135.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.". Hum. Mol. Genet. 13 (15): 1535–49. 2005. doi:10.1093/hmg/ddh167. PMID 15175272.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
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