Biology:ABL2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.

Function

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.

Interactions

ABL2 has been shown to interact with three proteins: Abl gene, catalase, and SORBS2. The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene. Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.

Further reading

• "Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts". Journal of Cell Science 122 (Pt 19): 3441–3454. October 2009. doi:10.1242/jcs.039859. PMID 19759284. 
• "The Abl family kinases: mechanisms of regulation and signaling". Advances in Cancer Research 85: 51–100. 2003. doi:10.1016/S0065-230X(02)85003-5. ISBN 978-0-12-006685-8. PMID 12374288. 
• "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction". Molecular and Cellular Biology 12 (11): 5087–5093. November 1992. doi:10.1128/mcb.12.11.5087. PMID 1383690. 
• "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases". Proceedings of the National Academy of Sciences of the United States of America 87 (15): 5802–5806. August 1990. doi:10.1073/pnas.87.15.5802. PMID 2198571. Bibcode: 1990PNAS...87.5802K. 
• "A novel human gene closely related to the abl proto-oncogene". Science 234 (4783): 1545–1548. December 1986. doi:10.1126/science.3787260. PMID 3787260. Bibcode: 1986Sci...234.1545K. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Subcellular localization of the Arg protein tyrosine kinase". Oncogene 13 (1): 193–197. July 1996. PMID 8700546. 
• "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene 13 (7): 1379–1385. October 1996. PMID 8875975. 
• "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry 272 (28): 17542–17550. July 1997. doi:10.1074/jbc.272.28.17542. PMID 9211900. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". The Biochemical Journal 330 ( Pt 2) (Pt 2): 923–932. March 1998. doi:10.1042/bj3300923. PMID 9480911. 
• "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". The Journal of Biological Chemistry 273 (27): 17186–17191. July 1998. doi:10.1074/jbc.273.27.17186. PMID 9642287. 
• "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Molecular and Cellular Biology 18 (11): 6795–6804. November 1998. doi:10.1128/mcb.18.11.6795. PMID 9774693. 
• "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". The Journal of Biological Chemistry 276 (15): 11465–11468. April 2001. doi:10.1074/jbc.C100050200. PMID 11278261. 
• "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene 20 (30): 3995–4006. July 2001. doi:10.1038/sj.onc.1204524. PMID 11494128. 
• "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". The Journal of Biological Chemistry 277 (26): 23747–23754. June 2002. doi:10.1074/jbc.M111794200. PMID 11956190. 
• "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". The EMBO Journal 21 (17): 4571–4582. September 2002. doi:10.1093/emboj/cdf446. PMID 12198159. 
• "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Letters 527 (1–3): 216–222. September 2002. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663. Bibcode: 2002FEBSL.527..216B. 
• "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proceedings of the National Academy of Sciences of the United States of America 100 (2): 443–448. January 2003. doi:10.1073/pnas.2436191100. PMID 12522270. Bibcode: 2003PNAS..100..443S. 

External links

• Genes,+abl at the US National Library of Medicine Medical Subject Headings (MeSH)
• Abelson+Leukemia+Virus at the US National Library of Medicine Medical Subject Headings (MeSH)
• ABL2 Info with links in the Cell Migration Gateway
• Human ABL2 genome location and ABL2 gene details page in the UCSC Genome Browser.