Biology:TEK tyrosine kinase

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

Function

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase.)

This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. TEK has also been suggested as a marker for nucleus pulposus progenitor cells, from the intervertebral disc, which upon activation by Angiopoietin-1 starts to multiply and differentiate.

Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.

In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.

Interactions

TEK tyrosine kinase has been shown to interact with:

• ANGPT2,
• Angiopoietin 1,
• DOK2.

See also

• Tie-2/Ang-1 signaling

Further reading

• "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase". Oncogene 11 (10): 2097–103. November 1995. PMID 7478529. 
• "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20". The Journal of Biological Chemistry 270 (38): 22632–8. September 1995. doi:10.1074/jbc.270.38.22632. PMID 7545683. 
• "A gene for familial venous malformations maps to chromosome 9p in a second large kindred". Journal of Medical Genetics 32 (3): 197–9. March 1995. doi:10.1136/jmg.32.3.197. PMID 7783168. 
• "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. September 1994. doi:10.1006/geno.1994.1457. PMID 7829101. 
• "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21". Genomics 23 (2): 512–3. September 1994. doi:10.1006/geno.1994.1536. PMID 7835909. 
• "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta". Oncogene 8 (3): 663–70. March 1993. PMID 8382358. 
• "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell 87 (7): 1161–9. December 1996. doi:10.1016/S0092-8674(00)81812-7. PMID 8980223. 
• "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell 87 (7): 1171–80. December 1996. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224. 
• "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2". Cell 87 (7): 1181–90. December 1996. doi:10.1016/S0092-8674(00)81814-0. PMID 8980225. 
• "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2". The Journal of Biological Chemistry 273 (29): 18514–21. July 1998. doi:10.1074/jbc.273.29.18514. PMID 9660821. 
• "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization". Circulation Research 83 (3): 233–40. August 1998. doi:10.1161/01.res.83.3.233. PMID 9710115. 
• "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology 10 (8): 1217–27. August 1998. doi:10.1093/intimm/10.8.1217. PMID 9723709. 
• "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene 17 (9): 1097–108. September 1998. doi:10.1038/sj.onc.1202115. PMID 9764820. 
• "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". The EMBO Journal 18 (4): 904–15. February 1999. doi:10.1093/emboj/18.4.904. PMID 10022833. 
• "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proceedings of the National Academy of Sciences of the United States of America 96 (5): 1904–9. March 1999. doi:10.1073/pnas.96.5.1904. PMID 10051567. Bibcode: 1999PNAS...96.1904V. 
• "Allelic and locus heterogeneity in inherited venous malformations". Human Molecular Genetics 8 (7): 1279–89. July 1999. doi:10.1093/hmg/8.7.1279. PMID 10369874. 
• "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". The Journal of Biological Chemistry 274 (43): 30896–905. October 1999. doi:10.1074/jbc.274.43.30896. PMID 10521483. 
• "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2". Oncogene 18 (43): 5948–53. October 1999. doi:10.1038/sj.onc.1202992. PMID 10557082. 

External links

• GeneReviews/NCBI/NIH/UW entry on Multiple Cutaneous and Mucosal Venous Malformations
• Overview of all the structural information available in the PDB for UniProt: Q02763 (Angiopoietin-1 receptor) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.