Biology:BMX (gene)
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Short description: Type of enzyme
 Generic protein structure example |
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.[1][2]
Function
Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[2]
Interactions
BMX has been shown to interact with:
References
- ↑ "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2". Oncogene 9 (12): 3683–8. December 1994. PMID 7970727.
- ↑ 2.0 2.1 "Entrez Gene: BMX BMX non-receptor tyrosine kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=660.
- ↑ "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. August 2001. doi:10.1074/jbc.M103129200. PMID 11382770.
- ↑ "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. May 2001. doi:10.1038/35074500. PMID 11331870.
- ↑ "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. December 2000. doi:10.1074/jbc.M007772200. PMID 11013262.
- ↑ "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. August 2002. doi:10.1074/jbc.M111933200. PMID 11877430.
Further reading
- "A tyrosine kinase profile of prostate carcinoma". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 5958–62. 1996. doi:10.1073/pnas.93.12.5958. PMID 8650201. Bibcode: 1996PNAS...93.5958R.
- "BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias". Br. J. Haematol. 94 (3): 455–60. 1996. doi:10.1111/j.1365-2141.1996.tb00091.x. PMID 8790141.
- "Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries". Circulation 96 (6): 1729–32. 1997. doi:10.1161/01.cir.96.6.1729. PMID 9323053.
- "The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta". Blood 90 (11): 4341–53. 1997. doi:10.1182/blood.V90.11.4341. PMID 9373245.
- "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3644–9. 1998. doi:10.1073/pnas.95.7.3644. PMID 9520419. Bibcode: 1998PNAS...95.3644Q.
- "Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells". J. Biol. Chem. 274 (16): 10983–9. 1999. doi:10.1074/jbc.274.16.10983. PMID 10196179.
- "Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation". Mol. Cell. Biol. 20 (6): 2043–54. 2000. doi:10.1128/MCB.20.6.2043-2054.2000. PMID 10688651.
- "The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner". Oncogene 19 (36): 4151–8. 2000. doi:10.1038/sj.onc.1203763. PMID 10962576.
- "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. 2001. doi:10.1074/jbc.M007772200. PMID 11013262.
- "Proteolytic activation of ETK/Bmx tyrosine kinase by caspases". J. Biol. Chem. 276 (21): 17672–8. 2001. doi:10.1074/jbc.M010964200. PMID 11278797.
- "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain". Nat. Cell Biol. 3 (5): 439–44. 2001. doi:10.1038/35074500. PMID 11331870.
- "Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells". J. Biol. Chem. 276 (31): 29403–9. 2001. doi:10.1074/jbc.M103129200. PMID 11382770.
- "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. 277 (11): 9351–7. 2002. doi:10.1074/jbc.M108537200. PMID 11751885.
- "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking". J. Biol. Chem. 277 (33): 30219–26. 2002. doi:10.1074/jbc.M111933200. PMID 11877430.
- "Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis". Mol. Cell. Biol. 22 (21): 7512–23. 2002. doi:10.1128/MCB.22.21.7512-7523.2002. PMID 12370298.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases". Biochim. Biophys. Acta 1645 (2): 123–32. 2003. doi:10.1016/S1570-9639(02)00524-1. PMID 12573241.
- "Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway". J. Biol. Chem. 278 (51): 51267–76. 2004. doi:10.1074/jbc.M310678200. PMID 14532277.
- "The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells". Oncogene 23 (10): 1854–62. 2004. doi:10.1038/sj.onc.1207308. PMID 14676838.
External links
- Human BMX genome location and BMX gene details page in the UCSC Genome Browser.
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