Biology:Tyrosine-protein kinase BLK

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. It is of the Src family of tyrosine kinases.

Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.

Further reading

• "Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.". Science 247 (4940): 332–6. 1990. doi:10.1126/science.2404338. PMID 2404338. Bibcode: 1990Sci...247..332D. 
• "Transcription of the blk gene in human B lymphocytes is controlled by two promoters.". J. Biol. Chem. 270 (43): 25968–75. 1995. doi:10.1074/jbc.270.43.25968. PMID 7592787. 
• "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. 1995. doi:10.1074/jbc.270.45.27072. PMID 7592958. 
• "Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.". J. Immunol. 154 (3): 1265–72. 1995. doi:10.4049/jimmunol.154.3.1265. PMID 7822795. 
• "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.". J. Biol. Chem. 269 (37): 22921–4. 1994. doi:10.1016/S0021-9258(17)31595-8. PMID 8083187. 
• "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.". Mol. Cell. Biol. 13 (9): 5877–87. 1993. doi:10.1128/MCB.13.9.5877. PMID 8395016. 
• "p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains.". J. Biol. Chem. 271 (12): 6952–62. 1996. doi:10.1074/jbc.271.12.6952. PMID 8636124. 
• "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.". Mol. Cell. Biol. 16 (9): 4735–43. 1996. doi:10.1128/MCB.16.9.4735. PMID 8756631. 
• "Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate.". Biochem. Biophys. Res. Commun. 234 (2): 325–9. 1997. doi:10.1006/bbrc.1997.6638. PMID 9177269. 
• "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.". J. Biol. Chem. 273 (14): 7783–6. 1998. doi:10.1074/jbc.273.14.7783. PMID 9525867. 
• "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. 1999. doi:10.1073/pnas.96.17.9557. PMID 10449731. Bibcode: 1999PNAS...96.9557O. 
• "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.". Eur. J. Hum. Genet. 10 (1): 17–25. 2002. doi:10.1038/sj.ejhg.5200750. PMID 11896452. 
• "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.". Cancer Lett. 188 (1–2): 121–6. 2003. doi:10.1016/S0304-3835(02)00055-1. PMID 12406557. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.". J. Biol. Chem. 279 (19): 19512–22. 2004. doi:10.1074/jbc.M309074200. PMID 14970218.