Biology:Glucose-1-phosphate guanylyltransferase
From HandWiki
| glucose-1-phosphate guanylyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.7.7.34 | ||||||||
| CAS number | 9033-13-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glucose-1-phosphate guanylyltransferase (EC 2.7.7.34) is an enzyme that catalyzes the chemical reaction
- GTP + alpha-D-glucose 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + GDP-glucose
Thus, the two substrates of this enzyme are GTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and GDP-glucose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-glucose-1-phosphate guanylyltransferase. Other names in common use include GDP glucose pyrophosphorylase, and guanosine diphosphoglucose pyrophosphorylase. This enzyme participates in starch and sucrose metabolism.
References
- "Nucleoside diphosphate glucose pyrophosphorylases in mast cell tumors". Biochim. Biophys. Acta 139 (2): 349–57. 1967. doi:10.1016/0005-2744(67)90038-1. PMID 6034677.
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