Biology:Glucose-1-phosphate guanylyltransferase
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Short description: Class of enzymes
| Glucose-1-phosphate guanylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.34 | ||||||||
| CAS number | 9033-13-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Glucose-1-phosphate guanylyltransferase (EC 2.7.7.34) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The enzyme characterised from mast cell tumors combines guanosine triphosphate and glucose 1-phosphate to give GDP-glucose, with pyrophosphate (PPi) as a byproduct.[1][2] In Streptomyces venezuelae this reaction is part of the biosynthetic pathway to trehalose 6-phosphate.[3]
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-glucose-1-phosphate guanylyltransferase. Other names in common use include GDP glucose pyrophosphorylase, and guanosine diphosphoglucose pyrophosphorylase.[4]
References
- ↑ Danishefsky, I.; Heritier-Watkins, O. (1967). "Nucleoside diphosphate glucose pyrophosphorylases in mast cell tumors". Biochimica et Biophysica Acta (BBA) - Enzymology 139 (2): 349–357. doi:10.1016/0005-2744(67)90038-1. PMID 6034677.
- ↑ Schomburg, Dietmar; Stephan, Dörte (1997). "Glucose-1-phosphate guanylyltransferase". Enzyme Handbook. pp. 645–647. doi:10.1007/978-3-642-59025-2_115. ISBN 978-3-642-47773-7.
- ↑ Asención Diez, Matías D.; Miah, Farzana; Stevenson, Clare E.M. et al. (2017). "The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae". Journal of Biological Chemistry 292 (3): 945–954. doi:10.1074/jbc.M116.758664. PMID 27903647.
- ↑ Enzyme 2.7.7.34 at KEGG Pathway Database.
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