Biology:Isotuberculosinol synthase

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Isotuberculosinol synthase
Identifiers
EC number3.1.7.9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Isotuberculosinol synthase (EC 3.1.7.9, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming).[1][2] This enzyme catalyses the following chemical reaction

tuberculosinyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (13S)-isotuberculosinol + diphosphate

This enzyme is present in species of Mycobacterium that cause tuberculosis.

References

  1. "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Bioscience, Biotechnology, and Biochemistry 75 (1): 75–81. 2011. doi:10.1271/bbb.100570. PMID 21228491. 
  2. "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Organic & Biomolecular Chemistry 9 (7): 2156–65. April 2011. doi:10.1039/c0ob00884b. PMID 21290071. 

External links