Biology:LETM1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Leucine zipper-EF-hand containing transmembrane protein 1 is a protein that in humans is encoded by the LETM1 gene.

Structure

The LETM1 protein has a transmembrane domain and a casein kinase 2 and protein kinase C phosphorylation site. The LETM1 gene is expressed in the mitochondria of many eukaryotes indicating that this is a conserved mitochondrial protein.

Function

LETM1 is a eukaryotic protein that is expressed in the inner membrane of mitochondria. Experiments performed with human cells have been interpreted to indicate that it functions as a component of a Ca²⁺/H⁺ antiporter. Experimental results with yeast cells have been interpreted as suggesting that LETM1 functions as a component of a K⁺/H⁺ antiporter. The Drosophila melanogaster LETM1 protein has been shown to functionally substitute for the K⁺/H⁺ antiporter function in yeast cells.

Clinical significance

Deletion of LETM1 is thought to be involved in the development of Wolf–Hirschhorn syndrome in humans.

See also

• LETM1-like protein family

Further reading

• "Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death". Cancer Research 69 (8): 3397–404. Apr 2009. doi:10.1158/0008-5472.CAN-08-3235. PMID 19318571. 
• "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics 60 (2): 218–25. Sep 1999. doi:10.1006/geno.1999.5881. PMID 10486213. 
• "The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome". The Journal of Biological Chemistry 279 (29): 30307–15. Jul 2004. doi:10.1074/jbc.M403607200. PMID 15138253. 
• "Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L". Journal of Cell Science 121 (Pt 15): 2588–600. Aug 2008. doi:10.1242/jcs.026625. PMID 18628306. 
• "Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis". Cellular Signalling 21 (5): 767–77. May 2009. doi:10.1016/j.cellsig.2009.01.020. PMID 19168126. 
• "Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter". Science 326 (5949): 144–7. Oct 2009. doi:10.1126/science.1175145. PMID 19797662. Bibcode: 2009Sci...326..144J. 
• "Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1". PLOS ONE 5 (9): e12535. 2010. doi:10.1371/journal.pone.0012535. PMID 20824095. Bibcode: 2010PLoSO...512535H. 
• "LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability". Human Molecular Genetics 17 (2): 201–14. Jan 2008. doi:10.1093/hmg/ddm297. PMID 17925330. 
• "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801. 
• "Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells". Human Molecular Genetics 16 (17): 2061–71. Sep 2007. doi:10.1093/hmg/ddm154. PMID 17606466. 
• "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE 5 (9): e12862. 2010. doi:10.1371/journal.pone.0012862. PMID 20877624. Bibcode: 2010PLoSO...512862H. 
• "LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein". Genomics 83 (2): 254–61. Feb 2004. doi:10.1016/j.ygeno.2003.08.013. PMID 14706454. 
• "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics 7 (3): 499–508. Mar 2008. doi:10.1074/mcp.M700325-MCP200. PMID 18029348. 

This article incorporates text from the public domain Pfam and InterPro: IPR011685

This article incorporates text from the United States National Library of Medicine, which is in the public domain.