Biology:Mitochondrial ribosomal protein L10
 Generic protein structure example |
39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.[1][2]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[2]
References
- ↑ "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem 276 (47): 43958–69. Nov 2001. doi:10.1074/jbc.M106510200. PMID 11551941.
- ↑ 2.0 2.1 "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124995.
Further reading
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.". Biochem. Biophys. Res. Commun. 314 (2): 335–50. 2004. doi:10.1016/j.bbrc.2003.12.091. PMID 14733910.
- "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. 2003. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1–2): 65–70. 2001. doi:10.1006/geno.2001.6622. PMID 11543634.
- "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828–36. 1999. doi:10.1074/jbc.273.52.34828. PMID 9857009.
- "RNA binding proteins of the large subunit of bovine mitochondrial ribosomes.". Nucleic Acids Res. 16 (6): 2565–83. 1988. doi:10.1093/nar/16.6.2565. PMID 3129699.
External links
- Overview of all the structural information available in the PDB for UniProt: Q7Z7H8 (39S ribosomal protein L10, mitochondrial) at the PDBe-KB.
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