Biology:Cholecystokinin receptor
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Short description: G-protein coupled receptor
| cholecystokinin A receptor | |
|---|---|
| Identifiers | |
| Symbol | CCKAR |
| NCBI gene | 886 |
| HGNC | 1570 |
| OMIM | 118444 |
| RefSeq | NM_000730 |
| UniProt | P32238 |
| Other data | |
| Locus | Chr. 4 p15.2-p15.1 |
| cholecystokinin B receptor | |
|---|---|
| Identifiers | |
| Symbol | CCKBR |
| NCBI gene | 887 |
| HGNC | 1571 |
| OMIM | 118445 |
| RefSeq | NM_176875 |
| UniProt | P32239 |
| Other data | |
| Locus | Chr. 11 p15.4 |
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
| Protein | Gene | Tissue distribution | Preferred ligand | Function | Mechanism |
|---|---|---|---|---|---|
| CCKA (CCK1) | CCKAR | primarily gastrointestinal tract, lesser amounts in the CNS | sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK | stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility | Gq[3][4] |
| CCKB (CCK2) | CCKBR | primarily CNS, lesser amounts in the gastrointestinal tract | gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) | regulation of nociception, anxiety, memory and hunger | Gq/G11[4] |
References
- ↑ "International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors". Pharmacological Reviews 51 (4): 745–781. December 1999. PMID 10581329. http://pharmrev.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10581329.
- ↑ "Cholecystokinin and gastrin receptors". Physiological Reviews 86 (3): 805–847. July 2006. doi:10.1152/physrev.00014.2005. PMID 16816139.
- ↑ "G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family". The American Journal of Physiology 274 (4 Pt 1): G607–G613. April 1998. doi:10.1152/ajpgi.1998.274.4.g607. PMID 9575840.
- ↑ 4.0 4.1 "Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database" (in en). IUPHAR/BPS Guide to Pharmacology CITE 2019 (4). 2019-09-16. doi:10.2218/gtopdb/F15/2019.4.
External links
- Cholecystokinin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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