Biology:PI4KA
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.[1][2][3]
Function
This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.[3]
Clinical significance
The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).[4] Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein.[5]
References
- ↑ "Cloning and characterization of a human phosphatidylinositol 4-kinase". J Biol Chem 269 (46): 28878–84. Dec 1994. doi:10.1016/S0021-9258(19)61989-7. PMID 7961848.
- ↑ "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase". J Biol Chem 271 (20): 12088–94. Aug 1996. doi:10.1074/jbc.271.20.12088. PMID 8662589.
- ↑ 3.0 3.1 "Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5297.
- ↑ "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe 9 (1): 32–45. January 2011. doi:10.1016/j.chom.2010.12.002. PMID 21238945.
- ↑ "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLOS Pathog. 9 (5): e1003359. May 2013. doi:10.1371/journal.ppat.1003359. PMID 23675303.
Further reading
- "Phosphatidylinositol 4-kinases.". Eur. J. Biochem. 253 (2): 357–70. 1998. doi:10.1046/j.1432-1327.1998.2530357.x. PMID 9654085.
- "Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes". Biochem. J. 284 (Pt 1): 39–45. 1992. doi:10.1042/bj2840039. PMID 1318025.
- "Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling". Science 268 (5214): 1188–90. 1995. doi:10.1126/science.7761838. PMID 7761838. Bibcode: 1995Sci...268.1188K.
- "Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". Mol. Cell. Biol. 13 (12): 7708–17. 1994. doi:10.1128/mcb.13.12.7708. PMID 8246987.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". J. Biol. Chem. 272 (46): 29174–80. 1997. doi:10.1074/jbc.272.46.29174. PMID 9360995.
- "Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230". Biochim. Biophys. Acta 1437 (3): 341–56. 1999. doi:10.1016/s1388-1981(99)00029-3. PMID 10101268.
- "Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor". J. Biol. Chem. 277 (23): 20293–300. 2002. doi:10.1074/jbc.M200831200. PMID 11907035.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. 33 (1): 46–52. 2003. doi:10.1002/immu.200390006. PMID 12594831.
- "Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells". Oncogene 23 (8): 1566–74. 2004. doi:10.1038/sj.onc.1207287. PMID 14676841.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. 2005. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.
- "Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases". J. Biol. Chem. 280 (11): 10501–8. 2005. doi:10.1074/jbc.M414304200. PMID 15634669.
- "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen". Thromb. Haemost. 93 (2): 311–8. 2005. doi:10.1160/TH04-08-0503. PMID 15711748.
- "Lipid and peptide control of phosphatidylinositol 4-kinase IIalpha activity on Golgi-endosomal Rafts". J. Biol. Chem. 281 (7): 3757–63. 2006. doi:10.1074/jbc.M506527200. PMID 16249177.
- "CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen". Thromb. Haemost. 93 (2): 311–8. 2005. doi:10.1160/TH04-08-0503. PMID 15711748.
- "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe 9 (1): 32–45. 2011. doi:10.1016/j.chom.2010.12.002. PMID 21238945.
- "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLOS Pathog. 9 (5): e1003359. 2013. doi:10.1371/journal.ppat.1003359. PMID 23675303.
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