Biology:PLCB3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.

Further reading

• "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9. 1992. doi:10.1111/j.1432-1033.1992.tb17450.x. PMID 1333955. 
• "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. 1990. doi:10.1172/JCI114950. PMID 1979339. 
• "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. 1995. doi:10.1002/eji.1830250944. PMID 7589147. 
• "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics 26 (3): 467–72. 1995. doi:10.1016/0888-7543(95)80164-H. PMID 7607669. 
• "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene". Biochem. Biophys. Res. Commun. 212 (1): 190–5. 1995. doi:10.1006/bbrc.1995.1955. PMID 7612006. https://zenodo.org/record/1229464. 
• "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics 25 (2): 568–9. 1995. doi:10.1016/0888-7543(95)80060-Y. PMID 7789993. 
• "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
• "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. 1998. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
• "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta 1393 (1): 173–8. 1998. doi:10.1016/s0005-2760(98)00074-5. PMID 9714794. 
• "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685. 
• "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. 1999. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
• "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. 2000. doi:10.1074/jbc.M001410200. PMID 10748023. 
• "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". J. Biol. Chem. 275 (24): 18418–23. 2000. doi:10.1074/jbc.M910211199. PMID 10748198. 
• "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
• "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta 1517 (1): 63–72. 2000. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617. 
• "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31. 2001. doi:10.1006/bbrc.2001.4329. PMID 11178984. 
• "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases". J. Biol. Chem. 276 (23): 19770–7. 2001. doi:10.1074/jbc.M006266200. PMID 11278298. 
• "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56. 2001. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525. 
• "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. 2002. doi:10.1006/viro.2002.1676. PMID 12482669.