Biology:PLCB3
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[1][2]
The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
Interactions
PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[3]
References
- ↑ "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81. March 1995. doi:10.1093/hmg/3.10.1775. PMID 7849701.
- ↑ "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5331.
- ↑ "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. June 2000. doi:10.1074/jbc.M001410200. PMID 10748023.
Further reading
- "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily". Eur. J. Biochem. 210 (2): 521–9. 1992. doi:10.1111/j.1432-1033.1992.tb17450.x. PMID 1333955.
- "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". J. Clin. Invest. 86 (6): 2117–24. 1990. doi:10.1172/JCI114950. PMID 1979339.
- "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700. 1995. doi:10.1002/eji.1830250944. PMID 7589147.
- "Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)". Genomics 26 (3): 467–72. 1995. doi:10.1016/0888-7543(95)80164-H. PMID 7607669.
- "Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene". Biochem. Biophys. Res. Commun. 212 (1): 190–5. 1995. doi:10.1006/bbrc.1995.1955. PMID 7612006. https://zenodo.org/record/1229464.
- "Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13". Genomics 25 (2): 568–9. 1995. doi:10.1016/0888-7543(95)80060-Y. PMID 7789993.
- "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J. Biol. Chem. 273 (28): 17749–55. 1998. doi:10.1074/jbc.273.28.17749. PMID 9651375.
- "Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3". Biochim. Biophys. Acta 1393 (1): 173–8. 1998. doi:10.1016/s0005-2760(98)00074-5. PMID 9714794.
- "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685.
- "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74. 1999. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
- "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. 2000. doi:10.1074/jbc.M001410200. PMID 10748023.
- "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". J. Biol. Chem. 275 (24): 18418–23. 2000. doi:10.1074/jbc.M910211199. PMID 10748198.
- "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
- "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta 1517 (1): 63–72. 2000. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617.
- "Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene". Biochem. Biophys. Res. Commun. 281 (1): 227–31. 2001. doi:10.1006/bbrc.2001.4329. PMID 11178984.
- "Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases". J. Biol. Chem. 276 (23): 19770–7. 2001. doi:10.1074/jbc.M006266200. PMID 11278298.
- "KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser". Mol. Cell. Endocrinol. 175 (1–2): 149–56. 2001. doi:10.1016/S0303-7207(01)00383-5. PMID 11325525.
- "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. 2002. doi:10.1006/viro.2002.1676. PMID 12482669.
![]() | Original source: https://en.wikipedia.org/wiki/PLCB3.
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