Biology:PLCD1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 is an enzyme that in humans is encoded by the PLCD1 gene. PLCd1 is essential to maintain homeostasis of the skin.

See also

Phospholipase C

Further reading

• Yagisawa H (2006). "Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+.". J. Cell. Biochem. 97 (2): 233–43. doi:10.1002/jcb.20677. PMID 16240320. 
• "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. 1991. doi:10.1172/JCI114950. PMID 1979339. 
• "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.". Eur. J. Immunol. 25 (9): 2695–700. 1995. doi:10.1002/eji.1830250944. PMID 7589147. 
• "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis.". J. Biol. Chem. 270 (10): 5495–505. 1995. doi:10.1074/jbc.270.10.5495. PMID 7890667. 
• "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties.". Protein Expr. Purif. 9 (2): 262–78. 1997. doi:10.1006/prep.1996.0682. PMID 9056492. 
• "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385. 
• "Phospholipase C-delta1 and oxytocin receptor signalling: evidence of its role as an effector.". Biochem. J. 331 (1): 283–9. 1998. doi:10.1042/bj3310283. PMID 9512491. 
• "Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function.". Biochem. Biophys. Res. Commun. 245 (3): 722–8. 1998. doi:10.1006/bbrc.1998.8307. PMID 9588182. 
• "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685. 
• "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.". J. Neurochem. 73 (4): 1363–74. 1999. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179. 
• "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.". J. Immunol. 164 (12): 6538–42. 2000. doi:10.4049/jimmunol.164.12.6538. PMID 10843712. 
• "Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.". Biochem. J. 356 (Pt 1): 137–42. 2001. doi:10.1042/0264-6021:3560137. PMID 11336645. 
• "Membrane targeting of C2 domains of phospholipase C-delta isoforms.". J. Biol. Chem. 277 (5): 3568–75. 2002. doi:10.1074/jbc.M109705200. PMID 11706040. 
• "Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta.". J. Biol. Chem. 277 (25): 22558–65. 2002. doi:10.1074/jbc.M202351200. PMID 11960991. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. 2003. doi:10.1006/viro.2002.1676. PMID 12482669. 
• "The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site.". J. Biol. Chem. 278 (32): 29995–30004. 2003. doi:10.1074/jbc.M301438200. PMID 12761218. 
• "GAP43 stimulates inositol trisphosphate-mediated calcium release in response to hypotonicity.". EMBO J. 22 (12): 3004–14. 2003. doi:10.1093/emboj/cdg294. PMID 12805215. 
• "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.". Biochem. Biophys. Res. Commun. 310 (3): 904–9. 2003. doi:10.1016/j.bbrc.2003.09.100. PMID 14550290. 

External links

• WikiGenes entry for PLCD1