Biology:Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
From HandWiki
| Phosphatidylinositol-4,5-bisphosphate 4-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.78 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].
References
- ↑ "Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology". The EMBO Journal 21 (19): 5069–78. October 2002. doi:10.1093/emboj/cdf522. PMID 12356723.
- ↑ "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proceedings of the National Academy of Sciences of the United States of America 102 (52): 18854–9. December 2005. doi:10.1073/pnas.0509740102. PMID 16365287.
- ↑ "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proceedings of the National Academy of Sciences of the United States of America 104 (43): 16834–9. October 2007. doi:10.1073/pnas.0708189104. PMID 17940011.
- ↑ "Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase". The Journal of General Physiology 129 (4): 267–83. April 2007. doi:10.1085/jgp.200609656. PMID 17389247.
External links
- Phosphatidylinositol-4,5-bisphosphate+4-phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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