Biology:Phosphoinositide 5-phosphatase
| phosphoinositide 5-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.36 | ||||||||
| CAS number | 9036-01-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme phosphoinositide 5-phosphatase (EC 3.1.3.36) catalyzes the reaction
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. Other names in common use include type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, and phosphatidyl-inositol-bisphosphate phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1UFW, 1W80, 2DNR, and 2QV2.
References
- "The triphosphoinositide phosphomonoesterase of brain tissue". Biochem. J. 91 (2): 244–50. 1964. doi:10.1042/bj0910244. PMID 4284485.
- "Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase". Biochim. Biophys. Acta 661 (2): 323–33. 1981. doi:10.1016/0005-2744(81)90021-8. PMID 6271223.
- Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
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